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KMID : 1123920090230051080
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Korean Journal of Oriental Physiology and Pathology
2009 Volume.23 No. 5 p.1080 ~ p.1086
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Effects of Gastrodiae Elata Pharmacopuncture at GB20 on Motor Control and Cognitive Function in Mild TBI Rats
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Kim Kyung-Yoon
Jung Hyun-Woo
Kim Gye-Yeop
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Abstract
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This study was designed to investigate the effects of Gastrodiae Elata Pharmacopuncure at GB20 on motor control and cognitive dysfunction recovery after mild traumatic brain injury in rats. Rats were divided into three groups; (1) no treatment after traumatic brain injury(experiment Ⅰ), (2) Treatment with NPA after traumatic brain injury(experiment Ⅱ), (3) Treatment with GEP after traumatic brain injury(experiment Ⅲ). In our study, we carried out behavioral test(Rotarod, Morris water maze) and immunohistochemistry study of the change BDNF in the hippocampus(pre, 7th, 14th day). In Rotarod test(motor control function) was significantly increased in the experimental group Ⅲ as compared with experimental group Ⅰ,Ⅱ on 7th(p<0.01) and 14th day(p<0.001). In Morris water maze test(cognitive function) was significantly decreased in the experimental group Ⅲ as compared with experimental group Ⅰ,Ⅱ on 14th day(p<0.001). In immunohistochemistric response of BDNF in the hippocampus, the experimental group Ⅲ was more immune response than the other groups on 14th day. These results imply that Gastrodiae Elata Pharmacopuncure at GB20 can play a role in facilitating recovery of motor control and cognitive function after mild traumatic brain injury in rats.
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KEYWORD
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gastrodiae elata pharmacopuncure(GEP), motor control, cognitive function, rotarod test, morris water maze, brain-derived neurotrophic factor(BDNF)
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